منابع مشابه
Op-cbio160301 2710..2712
Motivation: Transient S-sulfenylation of cysteine thiols mediated by reactive oxygen species plays a critical role in pathology, physiology and cell signaling. Therefore, discovery of new S-sulfenylated sites in proteins is of great importance towards understanding how protein function is regulated upon redox conditions. Results: We developed PRESS (PRotEin S-Sulfenylation) web server, a server...
متن کاملSite-specific mapping and quantification of protein S-sulfenylation in cells
Cysteine S-sulphenylation provides redox regulation of protein functions, but the global cellular impact of this transient post-translational modification remains unexplored. We describe a chemoproteomic workflow to map and quantify over 1,000 S-sulphenylation sites on more than 700 proteins in intact cells. Quantitative analysis of human cells stimulated with hydrogen peroxide or epidermal gro...
متن کاملProtein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding
The post-translational modification S-sulfenylation functions as a key sensor of oxidative stress. Yet the dynamics of sulfenic acid in proteins remains largely elusive due to its fleeting nature. Here we use single-molecule force-clamp spectroscopy and mass spectrometry to directly capture the reactivity of an individual sulfenic acid embedded within the core of a single Ig domain of the titin...
متن کاملFor Game Settings , Press S
Robust empirical support has been found for the idea that certain properties of the grammar are naturally non-symmetrical, as evidenced by the fact that certain logically possible word orders remain unattested in cross-linguistic inventories. It is proposed here that these linear non-symmetries arise as a result of the selection relation that drives syntactic structure building. A theory-indepe...
متن کاملThe redox biochemistry of protein sulfenylation and sulfinylation.
Controlled generation of reactive oxygen species orchestrates numerous physiological signaling events (Finkel, T. (2011) Signal transduction by reactive oxygen species. J. Cell Biol. 194, 7-15). A major cellular target of reactive oxygen species is the thiol side chain (RSH) of Cys, which may assume a wide range of oxidation states (i.e. -2 to +4). Within this context, Cys sulfenic (Cys-SOH) an...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2016
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btw301